Product Pathways - Growth Factors/Cytokines
Mouse Interleukin-17B (mIL-17B) #9584
|9584LC||50 µg (With Carrier)||---||In Stock||---|
|9584LF||50 µg (Carrier Free)||---||In Stock||---|
|9584SC||10 µg (With Carrier)||---||In Stock||---|
|9584SF||10 µg (Carrier Free)||---||In Stock||---|
Recombinant mouse IL-17B (mIL-17B) His21-Phe180 (Accession #NP_062381) was produced in E. coli at Cell Signaling Technology.
Recombinant mIL-17B has a Met on the amino terminus and has a calculated MW of 18,186. DTT-reduced and non-reduced protein migrate as 19 kDa polypeptides. The expected amino-terminal MHPRN of recombinant mIL-17B was verified by amino acid sequencing.
>98% as determined by SDS-PAGE of 6 μg reduced (+) and non-reduced (-) recombinant mIL-17B. All lots are greater than 98% pure.
The activity of mIL-17B was assessed by its ability to bind to IL-17RB in a functional ELISA. The concentration at which half-maximal binding was observed for each lot was 0.1-1.0 µg/ml.
The purity of recombinant mIL-17B was determined by SDS-PAGE of 6 µg reduced (+) and non-reduced (-) recombinant mIL-17B and staining overnight with Coomassie Blue.
Less than 0.01 ng endotoxin/1 μg mIL-17B.
With carrier: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.2 containing 20 μg BSA per 1 μg mIL-17B. Carrier free: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.2.
IL-17B is a member of the IL-17 family of structurally related proteins (1). Unlike other IL-17 family members, IL-17B is a non-covalently linked homodimer (1,2). IL-17B is expressed by chondrocytes and neurons, and binds to the IL-17RB receptor (1-4). Human IL-17B has been shown to induce TNF-α and IL-1β from monocytic THP-1 cells and may be involved in neutrophil recruitment in vivo (3). However, the exact biological functions of IL-17B remain elusive.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.