Product Pathways - Development
β-Catenin (L54E2) Mouse mAb (PE Conjugate) #6898
|6898S||100 µl (50 tests)||---||In Stock||---|
|6898||carrier free and custom formulation / quantity||email request|
Applications Key: F=Flow Cytometry
Species predicted to react based on 100% sequence homology: Mouse, Rat, Monkey, Pig.
Specificity / Sensitivity
β-Catenin (L54E2) Mouse mAb (PE Conjugate) detects endogenous levels of total β-catenin protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human β-catenin protein.
This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in human cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated β-Catenin (L54E2) Mouse mAb (IF Preferred) #2677.
β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).
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- Morin, P.J. et al. (1997) Science 275, 1787-90.
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.