ACVR1 AntibodyProduct information
|100 µl (10 western blots)||-||Unavailable in your region|
Product Pathways - TGF-beta/Smad Signaling
ACVR1 Antibody #4398
|4398S||100 µl (10 western blots)||---||In Stock||---|
|4398||carrier free and custom formulation / quantity||email request|
|W||1:1000||Human, Mouse, Monkey||Endogenous||57||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
ACVR1 Antibody detects endogenous levels of total ACVR1 protein. The antibody also cross-reacts with 35 kDa and 95 kDa bands of unknown origin.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ACVR1 protein. Antibodies were purified by protein A and peptide affinity chromatography.
The activin A receptor type 1 (ACVR1) is a membrane associated serine/threonine kinase receptor that binds activin A and related TGF-β superfamily growth factors, including bone morphogenetic protein 2 (BMP2) and BMP4, 6 and 7 (1-3). Functional activin receptors are composed of a pair of type I and type II activin receptor proteins. Following ligand binding, ACVR1 is phosphorylated by its type II binding partner, which allows recruitment and activation of receptor regulated SMAD (R-Smad) proteins (4). Phosphorylation of R-Smad proteins results in their translocation to the nucleus where R-Smads stimulate transcription of target genes (5). Mutations in the corresponding ACVR1 gene are associated with the genetic developmental disorders hereditary hemorrhagic telangiectasia and fibrodysplasia ossificans progressive (6,7).
- Attisano, L. et al. (1993) Cell 75, 671-80.
- Macías-Silva, M. et al. (1998) J Biol Chem 273, 25628-36.
- Ho, C.C. and Bernard, D.J. (2009) Biol Reprod 81, 133-41.
- Attisano, L. et al. (1996) Mol Cell Biol 16, 1066-73.
- Attisano, L. and Wrana, J.L. (2000) Curr Opin Cell Biol 12, 235-43.
- Shore, E.M. et al. (2006) Nat Genet 38, 525-7.
- Letteboer, T.G. et al. (2005) Hum Genet 116, 8-16.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.