Product Pathways - Neuroscience
nNOS (C7D7) Rabbit mAb #4231
|4231S||100 µl (10 western blots)||---||In Stock||---|
|4231||carrier free and custom formulation / quantity||email request|
|W||1:1000||Human, Mouse, Rat||Endogenous||160||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation, IHC-P=Immunohistochemistry (Paraffin), IF-F=Immunofluorescence (Frozen)
Specificity / Sensitivity
nNOS (C7D7) Rabbit mAb detects endogenous levels of total nNOS protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser280 of human nNOS.
Western blot analysis of extracts from mouse and rat brain using nNOS (C7D7) Rabbit mAb.
Western blot analysis of extracts from wild-type (+/+) and nNOS null (-/-) mouse brain using nNOS (C7D7) Rabbit mAb (upper) and PSD95 Antibody #2507 (lower).
Immunohistochemical analysis of paraffin-embedded wild-type (+/+, left) or nNOS null (-/-, right) mouse brain, using nNOS (C7D7) Rabbit mAb.
Nitric Oxide Synthase (NOS) catalyzes the formation of nitric oxide (NO) and citruline from L-arginine, oxygen and cofactors. Three family members have been characterized: neuronal NOS (nNOS), which is found primarily in neuronal tissue; inducible NOS (iNOS), which is induced by interferon gamma and lipopolysaccharides in the kidney and cardiovascular system; and endothelial NOS (eNOS), which is expressed in blood vessels (1). NO is a messenger molecule with diverse functions throughout the body including the maintenance of vascular integrity, homeostasis, synaptic plasticity, long-term potentiation, learning, and memory (2,3).
- Wu, M. et al. (2009) PLoS One 4, e6430. Applications: Western Blotting.
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
U.S. Patent No. 5,675,063.
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