Product Pathways - Ca / cAMP / Lipid Signaling
Calreticulin Antibody #2891
|2891S||100 µl (10 western blots)||---||In Stock||---|
|2891||carrier free and custom formulation / quantity||email request|
|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||55||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
Calreticulin Antibody detects endogenous levels of total calreticulin protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide surrounding Gln65 of human calreticulin. Antibodies are purified by peptide affinity chromatography.
Calcium is a universal signaling molecule involved in many cellular functions such as cell motility, metabolism, protein modification, protein folding, and apoptosis. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin, and is released via the IP3 Receptor channel (1). Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. As such, calreticulin presumably does not alter protein folding but regulates proper timing for efficient folding and subunit assembly. Furthermore, calreticulin retains proteins in non-native conformation within the ER and targets them for degradation (2,3).
- Ma, L. et al. (2012) J Biol Chem 287, 1290-305. Applications: Western Blotting.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
- 7074 Anti-rabbit IgG, HRP-linked Antibody
- 9998 BSA
- 7727 Biotinylated Protein Ladder Detection Pack
- 2433 Calnexin Antibody
- 12238 Calreticulin (D3E6) XP® Rabbit mAb
- 9956 ER Stress Antibody Sampler Kit
- 2887 ERp57 (A484) Antibody
- 2881 ERp57 (G117) Antibody
- 2798 ERp72 Antibody
- 2104 Grp94 Antibody
- 3763 IP3 Receptor Antibody
- 9999 Nonfat Dry Milk
- 3760 Phospho-IP3 Receptor (Ser1756) Antibody
- 7720 Prestained Protein Marker, Broad Range (Premixed Format)
- 6883 SignalFire™ ECL Reagent
- 12757 SignalFire™ Elite ECL Reagent
- 12630 SignalFire™ Plus ECL Reagent
- 9997 Tris Buffered Saline with Tween® 20 (TBST-10X)
This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.