Product Pathways - DNA Damage
SMC1 Antibody #4802
|4802S||100 µl (10 western blots)||---||In Stock||---|
|4802||carrier free and custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Species predicted to react based on 100% sequence homology: Rat, Chicken, Xenopus, Bovine.
Specificity / Sensitivity
SMC1 Antibody detects endogenous levels of total SMC1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to residues near the amino terminus of human SMC1. Antibodies are purified by protein A and peptide affinity chromatography.
Structural maintenance of chromosomes 1 (SMC1) protein is a chromosomal protein member of the cohesin complex that enables sister chromatid cohesion and plays a role in DNA repair (1,2). ATM/NBS1-dependent phosphorylation of SMC1 occurs at Ser957 and Ser966 in response to ionizing radiation (IR) as part of the intra-S-phase DNA damage checkpoint (3). SMC1 phosphorylation is ATM-independent in cells subjected to other forms of DNA damage, including UV light and hydroxyurea treatment (4). While phosphorylation of SMC1 is required for activation of the IR-induced intra-S-phase checkpoint, the precise mechanism is not well understood and may involve a conformational change that affects SMC1-SMC3 interaction (3).
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
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