Product Pathways - Metabolism
Glycogen Synthase Antibody #3893
|3893S||100 µl (10 western blots)||---||In Stock||---|
|3893||carrier free and custom formulation / quantity||email request|
|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||84||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation, F=Flow Cytometry
Species predicted to react based on 100% sequence homology: Horse.
Specificity / Sensitivity
Glycogen Synthase Antibody detects endogenous levels of total muscle glycogen synthase protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human glycogen synthase. Antibodies are purified by protein A and peptide affinity chromatography.
Western blot analysis of extracts from NIH/3T3, C6 and 293 cells, using Glycogen Synthase Antibody.
Glycogen synthase (GS) is a key enzyme in the regulation of glycogen synthesis. There are two main isoforms of mammalian GS: the muscle and the liver isoform (1-2). Muscle GS is expressed in several tissues, and liver GS appears to be tissue specific (3). GS is regulated by multi-site phosphorylation and by the binding of allosteric ligands. Phosphorylation leads to inactivation of GS, but activity is restored by the binding of the allosteric activator glucose-6-phosphate, which induces its dephosphorylation and activation (4).
- Fuchs, G. et al. (2011) J Mol Biol 410, 118-30. Applications: Western Blotting.
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