Product Pathways - Metabolism
Glycogen Synthase (15B1) Rabbit mAb #3886
|3886S||100 µl (10 western blots)||---||In Stock||---|
|3886||carrier free and custom formulation / quantity||email request|
|W||1:1000||Human, Mouse, Rat||Endogenous||84||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation, IHC-P=Immunohistochemistry (Paraffin)
Specificity / Sensitivity
Glycogen Synthase (15B1) Rabbit mAb detects endogenous levels of total muscle and liver glycogen synthase protein.
Source / Purification
Glycogen Synthase (15B1) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to the sequence of human glycogen synthase.
Western blot analysis of extracts from various cell lines, using Glycogen Synthase (15B1) Rabbit mAb.
Glycogen synthase (GS) is a key enzyme in the regulation of glycogen synthesis. There are two main isoforms of mammalian GS: the muscle and the liver isoform (1-2). Muscle GS is expressed in several tissues, and liver GS appears to be tissue specific (3). GS is regulated by multi-site phosphorylation and by the binding of allosteric ligands. Phosphorylation leads to inactivation of GS, but activity is restored by the binding of the allosteric activator glucose-6-phosphate, which induces its dephosphorylation and activation (4).
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
U.S. Patent No. 5,675,063.
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