PEN2 (D6G8) Rabbit mAbProduct information
PEN2 (D6G8) Rabbit mAb
|100 µl (10 western blots)||-||Unavailable in your region|
Product Pathways - Neuroscience
PEN2 (D6G8) Rabbit mAb #8598
|8598S||100 µl (10 western blots)||---||In Stock||---|
|8598||carrier free and custom formulation / quantity||email request|
|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||13||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
PEN2 (D6G8) Rabbit mAb recognizes endogenous levels of total PEN2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu92 of human PEN2 protein.
Presenilin Enhancer 2 (PEN2) is a small integral membrane glycoprotein that contains two recognized transmembrane domains. Both the N- and C-terminal domains are oriented into the lumen of the endoplasmic reticulum (1). PEN2, along with Presenilin 1, Presenilin 2, Nicastrin, and APH-1 form the protein complex γ-secretase (2). The proteinase BACE catalyses the initial step in APP processing by cleaving and releasing soluble APPβ (3). The remaining membrane bound APP is then cleaved by the γ-secretase complex, causing the release of amyloid β-peptide, the main constituent of amyloid plaques. These plaques are a hallmark of Alzheimer’s disease pathology (2). In addition to APP, the γ-secretase complex cleaves several other proteins and necessary presenilin-dependent signaling cascades, including the Notch pathway (4). It was found that PEN2 is an important part of the γ-secretase complex, and knocking it down results in reduced amounts of the complex, resulting in a loss of γ-secretase activity (5).
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
- 9784 Alzheimer's Disease Antibody Sampler Kit
- 7075 Anti-biotin, HRP-linked Antibody
- 7074 Anti-rabbit IgG, HRP-linked Antibody
- 9998 BSA
- 7727 Biotinylated Protein Ladder Detection Pack
- 9999 Nonfat Dry Milk
- 8502 PEN2 (D2G6) Rabbit mAb
- 5451 PEN2 Antibody
- 9997 Tris Buffered Saline with Tween® 20 (TBST-10X)
- 5887 γ Secretase Antibody Sampler Kit
This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.