FoxP2 (D55H9) Rabbit mAbProduct information
FoxP2 (D55H9) Rabbit mAb
|100 µl (10 western blots)||-||Unavailable in your region|
Product Pathways - Development
FoxP2 (D55H9) Rabbit mAb #5337
|5337S||100 µl (10 western blots)||---||In Stock||---|
|5337||carrier free and custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Species predicted to react based on 100% sequence homology: Mouse, Rat.
Specificity / Sensitivity
FoxP2 (D55H9) Rabbit mAb detects endogenous levels of total FoxP2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu623 of human FoxP2 protein.
Western blot analysis of extracts from 293 and HeLa cells using FoxP2 (D55H9) Rabbit mAb.
Immunoprecipitation/western blot analysis of lysates from 293 cells. Lane 1 contains lysate input (10%), lane 2 was immunoprecipitated with non-specific rabbit IgG, lane 3 was immunoprecipitated with FoxP2 (D55H9) Rabbit mAb #5337. Western blot analysis was performed using FoxP2 (D55H9) Rabbit mAb #5337.
Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors containing a sequence known as Forkhead box or winged helix DNA binding domain (1). The human genome contains 43 Fox proteins that are divided into subfamilies. The FoxP subfamily has four members, FoxP1 - FoxP4, which are broadly expressed and play important roles in organ development, immune response and cancer pathogenesis (2-4). The FoxP subfamily has several characteristics that are atypical among Fox proteins: their Forkhead domain is located at the carboxy-terminal region and they contain motifs that promote homo- and heterodimerization. FoxP proteins usually function as transcriptional repressors (4,5).
FoxP2 regulates lung and nerve system development (6-10). Mutations, including point mutation, truncation, deletion, and chromosomal translocation, involving FoxP2 are associated with an inherited form of speech and language disorder (11,12).
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