T-bet/TBX21 (V365) AntibodyProduct information
T-bet/TBX21 (V365) Antibody
|100 µl (10 western blots)||-||Unavailable in your region|
Product Pathways - Lymphocyte Signaling
T-bet/TBX21 (V365) Antibody #5214
|5214S||100 µl (10 western blots)||---||In Stock||---|
|5214||carrier free and custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
T-bet/TBX21 (V365) Antibody detects endogenous levels of total T-bet protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val365 of human T-bet/TBX21 protein. Antibodies are purified by protein A and peptide affinity chromatography.
The T-box gene family consists of transcription factors characterized by a related DNA-binding domain (T-box) of approximately 200 amino acids (1,2). The T-box genes exhibit diverse temporal and spatial patterns in the developing embryo. Studies have demonstrated members of this family play crucial roles during embryogenesis in a wide range of organisms by regulating cell fate decisions to establish the early body plan and to regulate later processes underlying organogenesis (3-5). Mutations in T-box genes are associated with many developmental defects (6). Recent studies also indicate potential roles in cancer by members of T-box family (7-9).
T-bet, also as known as TBX21, plays a critical role in development and maintenance of type 1 helper T (Th1) and T-bet deficient mice display impaired Th1 differentiation (10,11).
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- Rowley, M. et al. (2004) J Mammary Gland Biol Neoplasia 9, 109-18.
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- Ho, I.C. and Glimcher, L.H. (2002) Cell 109 Suppl, S109-20.
- Peng, S.L. (2006) Cell Mol Immunol 3, 87-95.
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
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