Plexin A4 (C5D1) Rabbit mAbProduct information
|100 µl (10 western blots)||-||Unavailable in your region|
Product Pathways - Neuroscience
Plexin A4 (C5D1) Rabbit mAb #3816
|3816S||100 µl (10 western blots)||---||In Stock||---|
|3816||carrier free and custom formulation / quantity||email request|
|W||1:1000||Mouse, Rat||Endogenous||212||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Species predicted to react based on 100% sequence homology: Human.
Specificity / Sensitivity
Plexin A4 (C5D1) Rabbit mAb detects endogenous levels of total Plexin A4 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a GST-fusion protein corresponding to residues from the human sequence of Plexin A4.
Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3).
Both Plexin A3 and A4 mediate the responses to class 3 Semaphorins in sensory and sympathetic neurons. In particular, Plexin A4 is responsible for signaling of Sema3A via neuropilin-1, while Plexin A3 is responsible for signaling of Sema3F via neuropilin-2 (4).
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
- 7074 Anti-rabbit IgG, HRP-linked Antibody
- 9998 BSA
- 7727 Biotinylated Protein Ladder Detection Pack
- 9999 Nonfat Dry Milk
- 3813 Plexin A1 Antibody
- 9968 Rho-GTPase Antibody Sampler Kit
- 6883 SignalFire™ ECL Reagent
- 12757 SignalFire™ Elite ECL Reagent
- 12630 SignalFire™ Plus ECL Reagent
- 9997 Tris Buffered Saline with Tween® 20 (TBST-10X)
This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
U.S. Patent No. 7,429,487, foreign equivalents, and child patents deriving therefrom.