DARPP-32 Blocking PeptideProduct information
|100 µg||-||Unavailable in your region|
Product Pathways - Neuroscience
DARPP-32 Blocking Peptide #1081
|1081S||100 µg||---||In Stock||---|
|1081||carrier free and custom formulation / quantity||email request|
This product is assembled upon order. Please allow up to three weeks for your product to be processed.
This peptide is used to block DARPP-32 (19A3) Rabbit mAb #2306 reactivity in dot blot protocols.
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. The peptide blocks DARPP-32 (19A3) Rabbit mAb #2306 signal in dot blot.
Directions For Use
Use as a blocking reagent to evaluate the specificity of antibody reactivity in dot blot protocols.
DARPP-32 (dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000) is a cytosolic protein highly enriched in medium-sized spiny neurons of the neostriatum (1). It is a bifunctional signaling molecule that controls serine/threonine kinase and serine/threonine phosphatase activity (2). Dopamine stimulates phosphorylation of DARPP-32 through D1 receptors and activation of PKA. PKA phosphorylation of DARPP-32 at Thr34 converts it into an inhibitor of protein phosphatase 1 (1). DARPP-32 is converted into an inhibitor of PKA when phosphorylated at Thr75 by cyclin-dependent kinase 5 (CDK5) (2). Mice containing a targeted deletion of the DARPP-32 gene exhibit an altered biochemical, electrophysiological, and behavioral phenotype (3).
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
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