UBR5 AntibodyProduct information
|100 µl (10 western blots)||-||Unavailable in your region|
Product Pathways - Protein Stability
UBR5 Antibody #8755
|8755S||100 µl (10 western blots)||---||In Stock||---|
|8755||carrier free and custom formulation / quantity||email request|
|W||1:1000||Human, Mouse, Monkey||Endogenous||300||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Species predicted to react based on 100% sequence homology: Dog, Pig.
Specificity / Sensitivity
UBR5 Antibody recognizes endogenous levels of total UBR5 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human UBR5 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Human E3 identified by differential display (UBR5/EDD) is a HECT domain-containing ubiquitin E3 ligase of the N-end rule pathway that promotes the ubiquitination and proteasomal degradation of proteins harboring N-degrons (1-3). UBR5 represents an ortholog of HYD, the Drosophila hyperplastic discs tumor suppressor gene product but has been found to be overexpressed in breast and ovarian cancers, suggesting a possible role in promoting tumor development (4,5). Research studies have demonstrated that UBR5 is functional within the nucleus as it participates in DNA damage signaling by controlling the activities of Chk2, TopBP1, and RNF168 (6-9). Recently, UBR5 was shown to play a novel role in immune cell function by regulating RORγt stability and IL-17 production by Th17 cells (10).
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- Gudjonsson, T. et al. (2012) Cell 150, 697-709.
- Rutz, S. et al. (2015) Nature 518, 417-21.
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
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