STIM2 AntibodyProduct information
|100 µl (10 western blots)||-||Unavailable in your region|
Product Pathways - Ca / cAMP / Lipid Signaling
STIM2 Antibody #4917
|4917S||100 µl (10 western blots)||---||In Stock||---|
|4917||carrier free and custom formulation / quantity||email request|
|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||100||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IF-IC=Immunofluorescence (Immunocytochemistry)
Specificity / Sensitivity
STIM2 Antibody detects endogenous levels of total STIM2 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human STIM2. Antibodies are purified by protein A and peptide affinity chromatography.
Ca2+ is a key second messenger in many intracellular signaling pathways. Ca2+ signals control many cellular functions ranging from short-term responses such as contraction and secretion to longer-term regulation of cell growth and proliferation (1,2). Stromal interaction molecules (STIMs) function as Ca2+ sensors that detect changes in Ca2+ content in intracellular Ca2+ stores (3). STIM1 is conserved, ubiquitously expressed, and functions as an endoplasmic reticulum (ER) Ca2+ sensor that migrates from the ER Ca2+ store to the plasma membrane where it activates calcium-release-activated calcium (CRAC) channels when the ER Ca2+ store is low (4). STIM1 is a potential tumor suppressor; defects in STIM1 may cause rhabdomyosarcoma and rhabdoid tumors (5). STIM1 can either homodimerize or form heterodimers with STIM2. STIM2 possesses a high sequence identity to STIM1 and can function as an inhibitor of STIM1-mediated plasma membrane store-operated Ca2+ entry (6). However, further investigation is required to elucidate the true physiological function of STIM2.
- Berridge, M.J. et al. (2000) Nat Rev Mol Cell Biol 1, 11-21.
- Berridge, M.J. et al. (2003) Nat Rev Mol Cell Biol 4, 517-29.
- Zheng, L. et al. (2008) Biochem Biophys Res Commun 369, 240-6.
- Zhang, S.L. et al. (2005) Nature 437, 902-5.
- Manji, S.S. et al. (2000) Biochim Biophys Acta 1481, 147-55.
- Soboloff, J. et al. (2006) Curr Biol 16, 1465-70.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
DRAQ5 is a registered trademark of Biostatus Limited.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.