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Horizon Diagnostics


Independent external controls to routinely monitor the performance of your workflows and assays.

Company Profile

Horizon is a leading provider of genetically defined, human genomic reference standards, including Formalin-Fixed Paraffin-Embedded (FFPE) cell line sections and purified genomic DNA (gDNA). HDx™ Reference Standards offer a sustainable source of reference material to laboratories, proficiency schemes and manufacturers, providing an unprecedented level of control.

Drawing upon our proprietary genome editing platform, we engineer clinically relevant cancer genes in human cell lines, exactly as they occur in patient tumors. In this way we are able to define virtually every characteristic of our reference standards, from the molecular constitution of the genome to DNA output associated with each product batch. These standards have been made available in a variety of formats including gDNA aliquots, FFPE slices, Fluorescence In Situ Hybridization (FISH) material and Immunohistochemistry (IHC) assays.

HDx Reference Standards are already having a profound impact on the molecular laboratories that have adopted them:

  • Validating the sensitivity and Limit of Detection (LOD) of molecular assays
  • Calibrating the sensitivity of assays in order to maintain quality control
  • Controlling pre-analytical processes, including DNA extraction and quantitation
  • Comparing  assay performance between platforms, assays and users
  • Improving standards by providing materials for staff training and proficiency scheme

>> What are Reference Standards?

Supporting documents

Application notes:

BIOKÉ is the exclusive distributor of Horizon Diagnostics in The Netherlands.

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