Product Pathways - Metabolism
PFKL Antibody #8175
|8175S||100 µl (10 western blots)||---||In Stock||---|
|8175||carrier free and custom formulation / quantity||email request|
|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||78||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
PFKL Antibody recognizes endogenous levels of total PFKL protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PFKL protein. Antibodies are purified by protein A and peptide affinity chromatography.
Phosphofructokinase (PFK) catalyzes the phosphorylation of fructose-6-phosphate in glycolysis (1). There are three isozymes: muscle-type, liver-type, and platelet-type (2). The liver-type PFK (PFKL) is the predominant subunit of PFK found in the liver (1,3). Research studies have shown that because of its location on chromosome 21, this enzyme is overexpressed in Down Syndrome/trisomy 21 (3,4). PFKL also may have a role in the physiological response to a low fat diet (5).
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
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