Product Pathways - Cell Cycle / Checkpoint
Eg5 (4H3-1F12) Mouse mAb #4203
|4203S||100 µl (10 western blots)||---||In Stock||---|
|4203||carrier free and custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
Eg5 (4H3-1F12) Mouse mAb recognizes endogenous levels of total Eg5 (Kif11) protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a recombinant amino-terminal fragment of human Eg5 protein.
Western blot analysis of extracts form HeLa and 293 cells using Eg5 (4H3-1F12) Mouse mAb.
Eg5 (also called kinesin-like protein 11 or Kif11) belongs to the kinesin-like family of motor proteins important in chromosome positioning, centrosome separation, and mitotic spindle formation. Phosphorylation of Eg5 by mitotic kinases regulates its activity by modulating its association with microtubules (1,2). Because anti-mitotic chemotherapeutic drugs, such as taxanes, target microtubules and have pleiotropic and sometimes toxic effects, drugs that target microtubule-associated proteins such as Eg5 are currently in development (3-5).
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
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