Product Pathways - Cell Cycle / Checkpoint
Trf1 (BED5) Mouse mAb #3529
|3529S||100 µl (10 western blots)||---||In Stock||---|
|3529||carrier free and custom formulation / quantity||email request|
|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||60||Mouse IgG1|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
Trf1 (BED5) Mouse mAb detects endogenous levels of total Trf1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant human Trf1.
Telomeres, the linear ends of chromosomes, are organized into T-loops to prevent them from being recognized by the cell as DNA double stranded breaks (DSBs) (1). A large number of proteins, including telomeric repeat binding factor proteins Trf1 and Trf2, are bound to the telomeres forming a complex of proteins known as shelterin or the telosome (2). Both Trf1 and Trf2 are known to regulate telomere length, participate in the DNA damage response, and contribute to chromosome stability (3-5).
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
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