Product Pathways - Ca / cAMP / Lipid Signaling
Calmodulin Antibody #4830
|4830S||100 µl (10 western blots)||---||In Stock||---|
|4830||carrier free and custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Species predicted to react based on 100% sequence homology: Human, Monkey, Xenopus, Pig.
Specificity / Sensitivity
Calmodulin Antibody detects endogenous levels of total calmodulin protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide surrounding Glu140 of human calmodulin. Antibodies are purified by peptide affinity chromatography.
Calmodulin is a ubiquitously expressed small protein mediating many cellular effects such as short-term and long-term memory, nerve growth, inflammation, apoptosis, muscle contraction and intracellular movement (1). Upon binding of four Ca2+ ions, calmodulin undergoes conformational changes, allowing this complex to bind to and activate many enzymes including protein kinases, protein phosphatases, ion channels, Ca2+ pumps, nitric oxide synthase, inositol triphosphate kinase, and cyclic nucleotide phosphodiesterase (2,3). Since calmodulin binds Ca2+ in a cooperative fashion, small changes in cytosolic Ca2+ levels lead to large changes in the level of active calmodulin and its target proteins (4).
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
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