ENPP1 Antibody (Human Specific)Product information
|100 µl (10 western blots)||-||Unavailable in your region|
Product Pathways - Metabolism
ENPP1 Antibody (Human Specific) #2070
|2070S||100 µl (10 western blots)||---||In Stock||---|
|2070||carrier free and custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
ENPP1 Antibody (Human Specific) detects endogenous levels of total ENPP1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln815 of human ENPP1. Antibodies were purified by protein A and peptide affinity chromatography.
Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) is a single-pass, type II transmembrane protein primarily involved in ATP hydrolysis at the plasma membrane. Targeting of ENPP1 to the basolateral cell surface relies on the presence of a carboxy-terminal di-leucine-based signal (1). ENPP1 plays important roles in bone mineralization and soft tissue calcification (2-5). Mutations in the corresponding ENPP1 gene cause generalized arterial calcification in infancy (GACI) and idiopathic infantile arterial calcification (IIAC) (6,7). ENPP1 inhibits insulin receptor function and overexpression of this enzyme causes insulin resistance and glucose intolerance in mice (8,9). Genetic variants of ENPP1 have been associated with obesity and type 2 diabetes (10-12).
- Bello, V. et al. (2001) Mol Biol Cell 12, 3004-15.
- Okawa, A. et al. (1998) Nat Genet 19, 271-3.
- Nakamura, I. et al. (1999) Hum Genet 104, 492-7.
- Harmey, D. et al. (2004) Am J Pathol 164, 1199-209.
- Hessle, L. et al. (2002) Proc Natl Acad Sci USA 99, 9445-9.
- Rutsch, F. et al. (2003) Nat Genet 34, 379-81.
- Ruf, N. et al. (2005) Hum Mutat 25, 98.
- Dong, H. et al. (2005) Diabetes 54, 367-72.
- Maddux, B.A. et al. (2006) Am J Physiol Endocrinol Metab 290, E746-9.
- Meyre, D. et al. (2005) Nat Genet 37, 863-7.
- Keene, K.L. et al. (2008) Diabetes 57, 1057-62.
- Bacci, S. et al. (2007) Curr Opin Clin Nutr Metab Care 10, 403-9.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.