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Believe in What You See.

The tumor microenvironment is complex. Your research doesn’t have to be.

Introducing Bethyl’s IHC PathPlex™ Multiplex Antibody Panels. Quickly detect multiple antigens in a single tissue section to gain clear understanding of the microenvironment without compromising samples.

Examples Ordering Information


Advantages of Multiplexing

With the advancement of immunotherapeutics, the urge to understand the tumor microenvironment has never been more pressing. Molecular histopathology has recently been shifting from single-marker immunohistochemistry towards multiplexed marker detection. Multiplex immunohistochemistry maximizes the amount of data acquired from an individual sample. Recent advances in multiplex immunohistochemistry and multispectral imaging facilitate accurate simultaneous analysis of multiple tissue markers. Clinically, understanding of the tumor microenvironment, and subsequent selection of appropriately-targeted therapies, can be augmented by profiling and localizing immune checkpoint proteins. The applications of multiplex immunohistochemistry are numerous, and span clinical, translational, and basic research applications.

 


IHC PathPlex™

To serve your multiplex research needs, Bethyl introduces IHC PathPlex™ panels to profile the complex tumor microenvironment. Each antibody has been validated for IHC and utilized in a multiplex format by our own scientists via proprietary processes to ensure the highest quality. With over 45 years of experience, Bethyl is recognized as a leading antibody manufacturer trusted by researchers around the world.

Pick any of the three core panels and add one or more antibody of your liking from the Bethyl immuno-oncology inventory (you will be forwarded to the Bethyl website).

 

IHC PathPlex Core Panels

T-Cell I/O Panel CD3 CD8 PD-L1
Lymphocyte Panel CD3 CD8 CD20
T, B & M Panel CD3 CD20 CD68

 

View the Immuno-Oncology Targets from Bethyl

(you will be forwarded to the Bethyl website).

 

The PathPlex Panels

BET A810-001 PathPlex™ Panel 1
(CD3E, CD8 alpha, PD-L1)
Reactivity: Human
Applications: IHC-IF, mIF
Includes: 1 each of A700-016, A700-044 and A700-020
BET A810-002 PathPlex™ Panel 2
(CD3E, CD8 alpha, CD20)
Reactivity: Human
Applications: IHC-IF, mIF
Includes: 1 each of A700-016, A700-044 and A500-017A
BET A810-003 PathPlex™ Panel 3
(CD3E, CD68, CD20)
Reactivity: Human
Applications: IHC-IF, mIF
Includes: 1 each of A700-016, A500-018A and A500-017A
BET A810-004 PathPlex™ Panel 4
(CD3E, Cytokeratin, CD8 alpha, CD68, PD-L1, FOXP3)
Reactivity: Human
Applications: IHC-IF, mIF
Includes: 1 each of A700-016, A500-019A, A700-044, A500-018A, A700-020 and A700-034
BET A810-005 PathPlex™ Panel 5
(CD3E, Cytokeratin, CD8 alpha, CD68, Ki-67, PD-L1)
Reactivity: Human
Applications: IHC-IF, mIF
Includes: 1 each of A700-016, A500-019A, A700-044, A500-018A, A700-021 and A700-020
BET A810-006 PathPlex™ Panel 6
(CD3E, Granzyme B, CD8 alpha, Cytokeratin, Ki-67, SOX10)
Reactivity: Human
Applications: IHC-IF, mIF
Includes: 1 each of A700-016, A700-022, A700-044, A500-019A, A700-021 and A700-080
BET A810-007 PathPlex™ Panel 7
(CD8 alpha, Cytokeratin, CD45RO, CD4, FOXP3)

Reactivity: Human
Applications: IHC-IF, mIF
Includes: 1 each of A700-044, A500-019A, A500-020A, A700-015 and A700-034
BET A810-008 PathPlex™ Panel 8
(CD3E, Cytokeratin, CD8 alpha, CD4, LAG3, FOXP3)
Reactivity: Human
Applications: IHC-IF, mIF
Includes: 1 each of A700-016, A500-019A, A700-044, A700-015, A700-027 and A700-034

 

Examples

Detection of human CD3 (yellow), CD8 (red), and CD20 (green) in FFPE tonsil by IHC-IF.
Rabbit anti-CD3e recombinant monoclonal [BL-298-5D12] (A700-016), rabbit anti-CD8a recombinant monoclonal [BLR044F] (A700-044), mouse anti-CD20 monoclonal [L26] (A500-017A). Secondary: HRP-conjugated goat anti-rabbit IgG (A120-501P) and HRP-conjugated goat anti-mouse IgG (A90-116P). Substrate: Opal™ 520, 620, and 690. Counterstain: DAPI (blue).

 

Detection of human CD8 (red), FoxP3 (green), and PD-L1 (orange) in FFPE breast carcinoma by IHC-IF.
Antibodies: CD8 (A700-044), FoxP3 (A700-034), and PD-L1 (A700-020). Substrate: Opal™ reagent. Counterstain: DAPI (blue).

 

Detection of human CD3 (teal), CD8 (green), CD68 (orange), CK (red), Ki67 (yellow) and PD-L1 (white) in FFPE HNSCC by IHC-IF.
Rabbit anti-CD3e recombinant monoclonal [BL-298-5D12] (A700-016), rabbit anti-CD8a recombinant monoclonal [BLR044F] (A700-044), mouse anti-CD68 monoclonal [KP-1] (A500-018A), mouse anti-cytokeratin monoclonal [AE1/AE3] (A500-019A), rabbit anti-Ki67 monoclonal [BLR021E] (A700-021) and rabbit anti-PD-L1 recombinant monoclonal [BLR020E] (A700-020). Secondary: HRP-conjugated goat anti-rabbit IgG (A120-501P) and HRP-conjugated goat anti-mouse IgG (A90-116P). Substrate: Opal™ 480, 520, 570, 620, 690 and 780. Counterstain: DAPI (blue).

 

 

Want to learn more these products or about Bethyl Laboratories

 

BIOKÉ is the exclusive distributor of the Bethyl Laboratories products in The Netherlands, Belgium and Luxembourg.

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