Product Introduction

• T4 pyrimidine DNA glycosylase
• Bifunctional DNA glycosylase with DNA N-glycosylase and AP lyase activities
• The N-glycosylase activity releases cis-syn cyclobutane pyrimidine dimers, including T^T, T^C and C^C, generating an AP site. The AP lyase activity cleaves an AP site via β-elimination, creating a 1 nucleotide DNA gap with 3'-α, β-unsaturated aldehyde and 5'-phosphate termini.
• Also known as T4 Endonuclease V