Mic-1 (Y60) AntibodyProduct information
|100 µl (10 western blots)||-||Unavailable in your region|
Product Pathways - TGF-beta/Smad Signaling
Mic-1 (Y60) Antibody #3249
|3249S||100 µl (10 western blots)||---||In Stock||---|
|3249||carrier free and custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Species predicted to react based on 100% sequence homology: Monkey.
Specificity / Sensitivity
Mic-1 (Y60) Antibody detects endogenous levels of the precursor form of Mic-1.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponsing to residues surrounding Tyr60 of human Mic-1. Antibodies are purified by protein A and peptide affinity chromatography.
Macrophage inhibitory cytokine-1 (Mic-1), also termed GDF15 (1), PTGF-β (2), PLAB (3), PDF (4), and NAG-1 (5), is a divergent member of the transforming growth factor-β (TGF-β) superfamily (6). Like other family members, Mic-1 is synthesized as an inactive precursor that undergoes proteolytic processing involving removal of an N-terminal hydrophobic signal sequence followed by cleavage at a conserved RXXR site generating an active C-terminal domain that is secreted as a dimeric protein. Mic-1 is highly expressed in the placenta and is also dramatically increased by cellular stress, acute injury, inflammation, and cancer. In the brain, Mic-1 is found in the choroid plexus and is secreted into the cerebrospinal fluid (7). It is also a transcriptional target of the p53 tumor suppressor protein and may serve as a biomarker for p53 activity (8,9). During tumor progression, Mic-1 has various effects on apoptosis, differentiation, angiogenisis, and metastasis, and may also contribute to weight loss during cancer (10,11).
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
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